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Index > Protein center > OAS1(Gene name) > Human
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  • OAS1 (Gene name),
  • 2'-5'-oligoadenylate synthase 1 (Protein name ),  OAS1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Gene name:
    OAS1(OIAS);
    Protein name:
    2'-5'-oligoadenylate synthase 1((2-5')oligo(A) synthase 1;2-5A synthase 1);
    Alternative:
    p46/p42 OAS;E18/E16;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homotetramer.
    Function:
    May play a role in mediating resistance to virus infection, control of cell growth, differentiation, and apoptosis.
    Subcellular Location:
    Mitochondrion Nucleus Microsome Endoplasmic reticulum Associated with different subcellular fractions such as mitochondrial, nuclear, and rough/smooth microsomal fractions.
    Protein Attributes:
    Sequence length:
    400
    Sequence:
    50:
    MMDLRNTPAK | SLDKFIEDYL | LPDTCFRMQI | NHAIDIICGF | LKERCFRGSS | 
    100:
    YPVCVSKVVK | GGSSGKGTTL | RGRSDADLVV | FLSPLTTFQD | QLNRRGEFIQ | 
    150:
    EIRRQLEACQ | RERAFSVKFE | VQAPRWGNPR | ALSFVLSSLQ | LGEGVEFDVL | 
    200:
    PAFDALGQLT | GGYKPNPQIY | VKLIEECTDL | QKEGEFSTCF | TELQRDFLKQ | 
    250:
    RPTKLKSLIR | LVKHWYQNCK | KKLGKLPPQY | ALELLTVYAW | ERGSMKTHFN | 
    300:
    TAQGFRTVLE | LVINYQQLCI | YWTKYYDFKN | PIIEKYLRRQ | LTKPRPVILD | 
    350:
    PADPTGNLGG | GDPKGWRQLA | QEAEAWLNYP | CFKNWDGSPV | SSWILLAESN | 
    400:
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    KEGG:
    String:
    Pfam:
    MIM:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human (2-5')oligo(A) synthase 1
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    E0330h
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    MSDS:
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    96T
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    ELISA Kit for Human (2-5')oligo(A) synthase 1
    Cat.:
    E0330p
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human (2-5')oligo(A) synthase 1
    Cat.:
    E0330r
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    Packing:
    96T
    CLIA Kit for Human (2-5')oligo(A) synthase 1
    Cat.:
    U0330p
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human (2-5')oligo(A) synthase 1
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    U0330r
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human (2-5')oligo(A) synthase 1
    Cat.:
    U0330h
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    MSDS:
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    Packing:
    96T
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    Polyclonal Antibody for Human (2-5')oligo(A) synthase 1
    Polyclonal Antibody for Human (2-5')oligo(A) synthase 1
    Cat.:
    P0330Rb-r
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human (2-5')oligo(A) synthase 1
    Cat.:
    P0330Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human (2-5')oligo(A) synthase 1
    Monoclonal Antibody for Human (2-5')oligo(A) synthase 1
    Monoclonal Antibody for Human (2-5')oligo(A) synthase 1
    Protein for Human (2-5')oligo(A) synthase 1
    Protein for Human (2-5')oligo(A) synthase 1
    Protein for Human (2-5')oligo(A) synthase 1

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Structure of two forms of the interferon-induced (2'-5') oligo A synthetase of human cells based on cDNAs and gene sequences."
      Benech P. , Mory Y. , Revel M. , Chebath J.
      EMBO J.4:2249-2256(1985) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS P41 AND P46);VARIANTS ASP-31; SER-162; THR-352 AND THR-361
      tissue: Fetal blood.
    2. 2.
      "Full-length sequence and expression of the 42 kDa 2-5A synthetase induced by human interferon."
      Wathelet M.G. , Moutschen S. , Cravador A. , Dewit L. , Defilippi P. , Huez G.A. , Content J.
      FEBS Lett.196:113-120(1986) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM P41);VARIANT SER-162
    3. 3.
      "Structure and expression of a cloned cDNA for human (2'-5')oligoadenylate synthetase."
      Shiojiri S. , Fukunaga R. , Ichii Y. , Sokawa Y.
      J. Biochem.99:1455-1464(1986) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM P41);VARIANT SER-162
    4. 4.
      "Cloning, sequencing, and expression of two murine 2'-5'-oligoadenylate synthetases. Structure-function relationships."
      Ghosh S.K. , Kusari J. , Bandyopadhyay S.K. , Samanta H. , Kumar R. , Sen G.C.
      J. Biol. Chem.266:15293-15299(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS P48 AND P41);VARIANT SER-162
    5. 5.
      "OAS1p44, a splice variant of the interferon induced human 2'-5' oligoadenylate synthetase."
      Andersen J.B. , Strandbygaard D.J. , Larsen S.E. , Justesen J.
      Submitted (2004-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM P44)
    6. 6.
      "The mammalian 2'-5' oligoadenylate synthetase gene family: evidence for concerted evolution of paralogous Oas1 genes in Rodentia and Artiodactyla."
      Perelygin A.A. , Zharkikh A.A. , Scherbik S.V. , Brinton M.A.
      J. Mol. Evol.63:562-576(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM P48);VARIANTS SER-162; THR-352 AND THR-361
    7. 7.
      "Susceptibility to infection by West Nile Virus: OAS1 (OAS1 2'-5' oligoadenylate synthetase gene) stop codon detected in exon 1 of a normal individual heterozygous for the gene."
      Lee M.-K. , Morshed M.G. , Jorgensen D.R. , Hasselback P. , Goh S.-H.
      Submitted (2006-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM P46);VARIANTS THR-352 AND THR-361
    8. 8.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM P41);VARIANT SER-162
    9. 9.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2003-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM P41);VARIANT SER-162
    10. 10.
      Suzuki Y. , Sugano S. , Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S.
      Submitted (2005-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM P41);VARIANT SER-162
      tissue: Small intestine.
    11. 11.
      "The finished DNA sequence of human chromosome 12."
      Scherer S.E. , Muzny D.M. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , Jackson A. , Khan Z.M. , Kovar-Smith C. , Lewis L.R. , more...
      Nature440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    12. 12.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM P41);VARIANT SER-162
      tissue: Brain.
      tissue: Uterus.
    13. 13.
      "New inducers revealed by the promoter sequence analysis of two interferon-activated human genes."
      Wathelet M.G. , Clauss I.M. , Nols C.B. , Content J. , Huez G.A.
      Eur. J. Biochem.169:313-321(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-28
    14. 14.
      "Interferon-responsive regulatory elements in the promoter of the human 2',5'-oligo(A) synthetase gene."
      Benech P. , Vigneron M. , Peretz D. , Revel M. , Chebath J.
      Mol. Cell. Biol.7:4498-4504(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-28
      tissue: Liver.
    15. 15.
      "Interferon-induced binding of nuclear factors to promoter elements of the 2-5A synthetase gene."
      Rutherford M.N. , Hannigan G.E. , Williams B.R.G.
      EMBO J.7:751-759(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-28
      tissue: Liver.
    16. 16.
      "Human 2-5A synthetase: characterization of a novel cDNA and corresponding gene structure."
      Saunders M.E. , Gewert D.R. , Tugwell M.E. , McMahon M. , Williams B.R.G.
      EMBO J.4:1761-1768(1985) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 231-400 (ISOFORM P48);INDUCTION
      tissue: Lymphoblast.
    17. 17.
      "Molecular cloning and sequence of partial cDNA for interferon-induced (2'-5')oligo(A) synthetase mRNA from human cells."
      Merlin G. , Chebath J. , Benech P. , Metz R. , Revel M.
      Proc. Natl. Acad. Sci. U.S.A.80:4904-4908(1983) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 255-364 (ISOFORM P41)
    18. 18.
      "Enzymatic activity of 2'-5'-oligoadenylate synthetase is impaired by specific mutations that affect oligomerization of the protein."
      Ghosh A. , Sarkar S.N. , Guo W. , Bandyopadhyay S. , Sen G.C.
      J. Biol. Chem.272:33220-33226(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF CYS-331; PHE-332 AND LYS-333
    19. 19.
      "The nature of the catalytic domain of 2'-5'-oligoadenylate synthetases."
      Sarkar S.N. , Ghosh A. , Wang H.W. , Sung S.S. , Sen G.C.
      J. Biol. Chem.274:25535-25542(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF ASP-75 AND ASP-77
    20. 20.
      "Characterization of the 2'-5'-oligoadenylate synthetase ubiquitin-like family."
      Eskildsen S. , Justesen J. , Schierup M.H. , Hartmann R.
      Nucleic Acids Res.31:3166-3173(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY;BIOPHYSICOCHEMICAL PROPERTIES;ENZYME REGULATION
    21. 21.
      "The human 2'-5'oligoadenylate synthetase family: unique interferon-inducible enzymes catalyzing 2'-5' instead of 3'-5' phosphodiester bond formation."
      Hovanessian A.G. , Justesen J.
      Biochimie89:779-788(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION
    22. 22.
      "The p59 oligoadenylate synthetase-like protein possesses antiviral activity that requires the C-terminal ubiquitin-like domain."
      Marques J. , Anwar J. , Eskildsen-Larsen S. , Rebouillat D. , Paludan S.R. , Sen G. , Williams B.R. , Hartmann R.
      J. Gen. Virol.89:2767-2772(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    23. 23.
      "Distinct antiviral roles for human 2',5'-oligoadenylate synthetase family members against dengue virus infection."
      Lin R.J. , Yu H.P. , Chang B.L. , Tang W.C. , Liao C.L. , Lin Y.L.
      J. Immunol.183:8035-8043(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
    24. 24.
      "Differential regulation of the OASL and OAS1 genes in response to viral infections."
      Melchjorsen J. , Kristiansen H. , Christiansen R. , Rintahaka J. , Matikainen S. , Paludan S.R. , Hartmann R.
      J. Interferon Cytokine Res.29:199-207(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
    25. 25.
      "Evolution of the 2'-5'-oligoadenylate synthetase family in eukaryotes and bacteria."
      Kjaer K.H. , Poulsen J.B. , Reintamm T. , Saby E. , Martensen P.M. , Kelve M. , Justesen J.
      J. Mol. Evol.69:612-624(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
    26. 26.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    27. 27.
      "The oligoadenylate synthetase family: an ancient protein family with multiple antiviral activities."
      Kristiansen H. , Gad H.H. , Eskildsen-Larsen S. , Despres P. , Hartmann R.
      J. Interferon Cytokine Res.31:41-47(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION
    28. 28.
      "Structural basis for cytosolic double-stranded RNA surveillance by human oligoadenylate synthetase 1."
      Donovan J. , Dufner M. , Korennykh A.
      Proc. Natl. Acad. Sci. U.S.A.110:1652-1657(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 1-347 IN COMPLEX WITH DSRNA; MAGNESIUM IONS AND ATP;FUNCTION;CATALYTIC ACTIVITY;COFACTOR;ENZYME REGULATION;MUTAGENESIS OF LYS-66; ASP-148 AND GLU-233
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